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板蓝根化学成分的研究(Ⅲ)

Studies on chemical constituents in root of Isatis indigotica Ⅲ

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【作者】 刘云海秦国伟丁水平吴晓云

【Author】 LIU Yun hai 1, QIN Guo wei 2, DING Shui ping 1, WU Xiao yun 2 (1 Tongji Hospital Affilliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei 430030, China; 2 Shanghai Institute of Materia Medica, Chinese

【机构】 华中科技大学同济医学院附属同济医院中国科学院上海药物研究所中国科学院上海药物研究所 湖北武汉430030上海200031湖北武汉430030上海200031

【摘要】 目的 提取分离板蓝根化学成分。方法 板蓝根用 95 %乙醇渗漉 ,不同极性溶剂分级萃取 ,再分别用硅胶和大孔树脂作柱层析分离 ,测定纯化合物的理化常数和波谱数据 ,鉴定化学结构。结果 从板蓝根中分得 2个化合物 ,分别命名为 3 -羟苯基喹唑酮〔3 - ( 2′- hydroxypheny1) - 4 ( 3 H) - quinazolinone〕,依靛蓝酮 ( isaindigodione)。结论 该 2个化合物为首次从板蓝根中分得

【Abstract】 Object To study chemical constituents of the root of Isatis indigotica Fort Methods The powdered plant material was percolated with 95% ethanol, the percolate was extracted with different solvents, the extract was subject to chromatography on silica gel column and macroporous resin column. The compounds were identitfied by their physicochemical properties and spectral data (MS, 1HNMR, 13 CNMR, UV and IR) Results Two compounds were obtained from the ethanol extracts of the plant root They are 3 (2′ hydroxyphenyl) 4(3H) quinazolinone and isaindigodione respectively Conclusion The two compounds were obtained from I. indigotica for the first time

【基金】 国家自然科学基金资助课题 ( No.39870 872 ) ;卫生部科学研究基金课题 ( No.98-2 -110 )
  • 【文献出处】 中草药 ,Chinese Traditional and Herbal Drugs , 编辑部邮箱 ,2002年02期
  • 【分类号】R284.1
  • 【被引频次】97
  • 【下载频次】1005
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