【摘要】 目的 :研究磷脂酶A2 (PLA2 )活性及其相关炎症介质在大鼠慢性常压低氧性肺动脉高压形成中的作用。方法 :2 9只健康SD大鼠随机分为正常对照组、单纯低氧组和低氧加白藜芦醇苷 (PD)组。右心导管法检测大鼠肺动脉压力 (mPAP) ,观察右室 /左室 +室间隔比值 (R/L +S)、血浆和肺匀浆中PLA2 、血栓素B2 (TXB2 )、6 -酮 -前列腺素F1α(6 -k -PGF1α)、丙二醛 (MDA)、超氧化物歧化酶 (SOD)水平的变化。结果 :低氧 3周后大鼠mPAP、R/L +S、血浆及肺匀浆中PLA2 活性、TXB2 、MDA含量显著升高 ;6 -k -PGF1α、SOD水平下降。用PD预处理后可减轻上述变化。结论 :PLA2 通过相关炎症介质及与自由基的相互作用在慢性低氧性肺动脉高压的形成中起着重要的介导作用更多还原

【Abstract】 AIM: To study the relationship between the activity of phospholipase A 2 (PLA 2) and chronic hypoxic pulmonary hypertension. METHODS: 29 healthy SD rats were randomly divided into normal control group, chronic hypoxic group and hypoxia plus Polidatin (PD) group. The model of rat chronic hypoxic pulmonary hypertension was made by method of intermittent isobaric hypoxia for 21 days. The mean pulmonary arterial pressure (mPAP) was measured by inserting a microcatheter into the pulmonary artery. RESULTS: After exposing hypoxia for 21 days, the mPAP, R/L+S, the PLA 2 activity, TXB 2, MDA in plasma and lung homogenate increased significantly, while 6-k-PGF 1α , SOD decreased significantly. Pretreatment with PD could relieve the changes mentioned above.CONCLUSION: PLA 2 plays an important inducing role through its metabolic products and the interactional radicals in the formation of chronic hypoxic pulmonary hypertension.更多还原