【摘要】 目的 :　探讨补充微量营养素对儿童生长发育的作用。方法 :　选择身高低于WHO标准 - 1 SD的 3～ 5岁儿童为受试对象 ,分为阴性对照组和 4个补充组 :锌 (Zn)、Zn+钙 (Ca)、Zn+Ca+维生素 A(VA)和 Ca+VA。按分组分别补充 Zn3 .5 mg,Ca2 5 0 mg,VA2 0 0 μg,每周5 d共持续 1 2 m;另选择身高正常的 3 4名儿童作为正常对照 ,每 3 m和 6 m分别对儿童进行体格检查和膳食调查 ,并进行骨密度测量。结果 :　 1 .补 Zn和补 Zn、Ca可使生长缓慢儿童身高增长速度明显高于对照组。2 .补 Zn、Ca、VA及补 Ca、VA可使儿童体重增加速度明显高于对照组。3 .补充Zn、Ca、VA可适当缓解生长缓慢儿童骨龄滞后现象 ,但不加速骨骼的成熟。结论 :　补充微量营养素可增加儿童身高、体重的增长速率 ,缓解骨龄滞后现象。更多还原

【Abstract】 Objective: To investigate the effect of micronutrients supplementation on growth retardation of children. Methods: 156 children whose heights were-1 SD below reference of WHO were included. They were randomly assigned to five groups: negative group, +Zn group, +Zn+Ca group, +Zn+Ca+VA group and +Ca+VA group. Supplementation continued for twelve months. Other 34 children of normal height were acted as normal group. Anthropometric and dietary investigation were measured every three or six months. Bone density was measured before and after supplementation. Results: 1. The height velocity in +Zn group (7.84 cm per year) and +Zn+Ca group (7.70 cm per year) was significantly higher than negative group (6.74 cm per year); 2. The weight velocity in +Zn+Ca+VA group (2.57 kg per year) and in +Ca+VA group (2.77 kg per year) was also significantly higher than negative group (2.19 kg per year). 3. Micronutrients supplementation could modify the delayed bone age, but did not accelerate the bone maturity. Conclusion: Micronutrients deficiency is the main problem that affect the growth of children, and proper supplementation can accelerate the growth velocity and modify the delayed bone age.更多还原