【摘要】 目的:观察:KTP激光心肌重建术（TMLR）对实验性心肌梗死中期血运动的影响。方法:家犬12只,结扎左前降支中段造成急性心肌梗死模型,随机分为TMLR组和对照组,TMLR激光在梗死区行TMLR,对照组则否。2一3月后,行^99mTc一MIBI门挖断层心肌灌注显像,重建左室短轴、水平长轴、垂直长轴图象,将左室心肌分为20个心肌节段,按^99mTc—MIBI摄取量分别为0—4分,比较其积分来评价两组动物心肌血运。结果:^99mTc—MI-BI SPECT心肌灌注显象显示,实验组和对照组在左室水平长轴、垂直长轴和短轴上显示大部分左室前壁、部分间壁及心尖部^99mTc—MIBI摄取明显减低或无摄取,与实验梗死部位相一致,两组心肌显像的总积分分别为20.0±8.9,23.6±4.7,两组之间比较无明显统计学差异（P>0.05）结论:KTP激光TMLR对急性心迹梗死犬2—3月后心肌运有改善的倾向,但效果不显著。更多还原

【Abstract】 Objective The study was aimed to assess the effects of experimental transmyocardial revascularization with frquency- double Nd:YAG(KTP) laser (TMLR) on myocardial blood flow in zcute myocardial infarction2 -Smonth. Methods: Left thoracotomy was performed in 12 adult mongrel dogs. The medius of the left anterior descending artery (LAD) was ligated to creat the acute myocardial infarction. TMLR was performed with KTP laser in the acute infarcted LAD territory in TMLR group (n=6) and without any treating in control group (n=6). Myocardial perfusion imaging with 99m Tc - sestamibi SPECT was performed 2 - 3months after acute myocardium infraction both groups. Results; Myocardial perfusion SPECT imaging showed radioactivity deficit or decreasing of ra-diodistribution in anterior, interventricular septum and aex in both groups. There was no significant difference on the myocardium scores of radiodistribution between two groups. Conclusion: TMLR with KTP laser didn’t improve myocardium perfusion 2 - 3 months after TMLR in acute myocardial infraction.更多还原