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β-环糊精衍生物对黄酮类药物的增溶作用
Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives
【Abstract】 The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.
【关键词】 相溶解度;
β-环糊精衍生物;
黄酮类药物;
增溶作用;
【Key words】 phase solubility; β cyclodextrin and its derivatives; flavonoids; solubility;
【Key words】 phase solubility; β cyclodextrin and its derivatives; flavonoids; solubility;
【基金】 国家自然科学基金 (2 0 172 0 3 5 );国家教育部优秀青年教师资助计划项目
- 【文献出处】 应用化学 ,Chinese Journal of Applied Chemistry , 编辑部邮箱 ,2002年07期
- 【分类号】O629
- 【被引频次】35
- 【下载频次】521