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β-环糊精衍生物对黄酮类药物的增溶作用

Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives

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【作者】 王茹林杨郁双少敏潘景浩

【Author】 WANG Ru Lin, YANG Yu, SHUANG Shao Min *, PAN Jing Hao(Department of Chemistry,Shanxi University,Taiyuan 030006)

【机构】 山西大学化学化工学院山西大学化学化工学院 太原030006现在山西医科大学基础医学院化学教研室太原030006太原030006

【Abstract】 The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.

【基金】 国家自然科学基金 (2 0 172 0 3 5 );国家教育部优秀青年教师资助计划项目
  • 【文献出处】 应用化学 ,Chinese Journal of Applied Chemistry , 编辑部邮箱 ,2002年07期
  • 【分类号】O629
  • 【被引频次】35
  • 【下载频次】521
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