【摘要】 目的 :观察纳洛酮对新生儿缺氧缺血性脑病 (HIE)的临床疗效。方法 :将 65例HIE患儿随机分为治疗组3 7例和对照组 2 8例 ,分别给予纳洛酮 0 .1mg·kg 1·d 1和一般常规治疗 ,均治疗 7d ,并行CT检查。结果 :两组平均临床症状消失时间差异有极显著性 (P <0 .0 1) ,CT好转率差异也有显著性 (P <0 .0 5 )。结论 :纳洛酮对HIE的疗效明显高于一般常规治疗 ,并发症较少更多还原

【Abstract】 Objective:To survey the clinical therapeutic effectiveness of naloxone in the treatment of neonatal hypoxic ischemic encephalopathy (HIE). Method:65 neonates with HIE were randomly divided into two groups. Patients of the naloxone treatment group( n =37) were given each a daily dose of 0.1 mg·kg 1 of naloxone via the intravenous route for one week. Neonates of the control group ( n =28) were subjected to the routine treatment, lasting 7 days too. Results:The average time of disappearance of clinical symptoms was significantly shorter in the treatment group than in the control group ( P <0.01) The rate of recovery from and alleviation of brain injury as revealed by CT was evidently higher in the treatment group than in the control group ( P <0.05). Conclusion:The therapeutic effectiveness of naloxone in the treatment of HIE was apparently better than that of routine therapy. Adverse reactions were rare in the use of naloxone.更多还原