节点文献

红丝线化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS OF LYCIANTHES BIFLORA

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 杨光忠; 赵松; 李援朝;

【Author】 WT4”,5BZ]YANG Guang zhong 1, ZHAO Song 2, LI Yuan chao 1 (1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China; 2. Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 20

【机构】 中国科学院上海药物研究所; 华东理工大学精细化工研究所; 中国科学院上海药物研究所 上海200031; 上海200237; 上海200031;

【摘要】 目的 研究红丝线 (Lycianthesbiflora)的化学成分。方法 应用各种色谱技术进行分离纯化 ,用IR ,MS ,1 HNMR ,1 3CNMR和各种 2D NMR技术鉴定化合物的结构 ,并进行初步的药理实验。结果 从红丝线分得 5个化合物 ,分别鉴定为biflorideA ( 1) ,N trans cinnamoyltyramine ( 2 ) ,liquiritigenin ( 3 ) ,N trans p coumaroyloctopamine ( 4 ) ,1 O β D glucopyranosyl 2 N 2′ hydroxypalmitoyl sphinga 4 trans 8 trans dienine ( 5 )。结论  1,2为新化合物 ,2对P 3 88白血病细胞有一定抑制作用 ,其余化合物皆首次从该植物中分得

【Abstract】 AIM To study the chemical constituents of Lycianthes biflora . METHODS Column chromatography was used to separate the chemical constituents. IR, MS, 1HNMR , 13 CNMR and 2D NMR technique were used to determine the structures of the isolated constituents. RESULTS Five compounds were isolated from this plant. Their structures were identified to be bifloride A (1), N trans cinnamoyltyramine (2), liquiritigenin (3), N trans p coumaroyloctopamine (4), 1 O β D glucopyranosyl 2 N 2′ hydroxypalmitoyl sphinga 4 trans 8 trans dienine (5). CONCLUSION Compounds 1 and 2 are new compounds, the others were isolated from this plant for the first time. Compound 2 showed inhibitory effects on P 388.

  • 【文献出处】 药学学报 ,Acta Pharmaceutica Sinica , 编辑部邮箱 ,2002年06期
  • 【分类号】R284
  • 【被引频次】32
  • 【下载频次】423
节点文献中: 

本文链接的文献网络图示:

本文的引文网络