【摘要】 目的:报告55例食管、贲门癌组织相关耐药基因的表达及其临床意义。方法:采用S-P免疫组化法对食管、贲门癌组织进行Pgp、MRP、GST-π、TopoⅡ检测。结果:食管、贲门癌组织中Pgp、MRP、GST-π、TopoⅡ表达阳性率分别为21.1％/25.0％、52.8％/50.0％、85.7％/60.0％、91.9％/92.8％,它们与食管、贲门癌的病变部位,TNM分期,病理类型,组织分化,淋巴结转移之间均无明显相关性(P>0.05)。结论:食管、贲门癌在恶变过程中相关耐药基因均有不同程度的表达,可作为一种分子标志物。它们以不同机制参与食管、贲门癌的多药耐药。联合检测有助于评估预后和指导术后化疗,提高综合治疗效果。更多还原

【Abstract】 Objective: To investigate clinical significance and expression level of the associated multi-drug resistance gene in 55cases with esophageal and cardiac cancer. Method: The expression of the Pgp, MRP, GST-π Topo Ⅱ of MDR genes in esophageal andcardiac cancer samples was detected by S-P immunohistochemistry. Result:The positive expressions of Pgp, MRP, GST-π Topo Ⅱ ofMDR genes in esophageal and cardiac cancer tissues were 21.5%/25.0% ,52.8%/50.0% ,85.7%/60.0% ,91.9%/92.8% , respectively. No correlations were noted between MDR genes and tumor position,TNM stage, pathological type,histological differen-tion and lymphonodus metastasis. Conclussion: The expression of MDR gene related to esophageal and cardiac cancer may act as one of molecular marker, and they take part in MDR by different mechanism. The combination detection of MDR gene will be useful to i-dentify the prognosis and direct to post-operative chemotherapy,elevate effect of comprehensive treatment.更多还原