【摘要】 目的:探索静脉尿激酶溶栓对老年人急性心肌梗死(AMI)的治疗价值及最佳溶栓剂量。方法:将98例老年AMI患者分成溶栓组和对照组,溶栓组又分2组,分别使用80万U和150万U的尿激酶进行溶栓治疗,观察他们的冠脉再通率、死亡率及并发症、副作用的发生情况。结果:相同年龄状况下,溶栓组的死亡率及主要并发症的发生率比对照组低(P<0.05)。80万U与150万U两种剂量尿激酶溶栓治疗时,冠脉再通率及死亡率无差异(P>0.05),而大出血、脑出血的发生率,80万U组比150万U组低(P<0.05)。结论:静脉尿激酶溶栓治疗能改善老年AMI的预后,降低死亡率。溶栓药物尿激酶的用量应以小剂量为宜。更多还原

【Abstract】 Objective: To research the effect of intravenous infusion with urokinase to thrombolysis and the best thrombolytic dose on elderly patients with myocardial Infarction (AMI) .Methods:98 elderly patients with AMI were divided into treatment groups and control one.The treatment groups were divided into two groups, which received 80 million units and 150 million units of UR.respec-tively,to observe their coronary patency,mortality,complications and side-effect of the drugs.Results: In same age the mortality and complications in treatment groups were lower than the control one( P < 0.05) . The incidence of complications of bleeding in group of 80 million u\ils was lower than group of 150 million units ( P > 0.05). Conclusion: Intravenous infusion with urokinase for thrombolysis was able to improve the prognosis and reduce the mortality in elderly cases.The dose of urokinase for thrombolysis suitable for elderly case was 80 million units.更多还原