【摘要】 环氧化酶是花生四烯酸转化为前列腺素途径中的一种关键酶。该酶有两种同功酶 :环氧化酶 - 1是组成型的 ,环氧化酶 - 2为诱导型。环氧化酶与炎症、阿尔茨海默病、肿瘤和动脉粥样硬化等疾病的发生、发展及有关药物的研发密切相关 ,一些非甾体抗炎药即是以环氧化酶 - 2为靶点。本文综述了环氧化酶 - 1和环氧化酶 - 2在生理、疾病中的地位和作用以及环氧化酶抑制剂的研究近况更多还原

【Abstract】 Cyclooxygenase(COX) is the key enzyme required for the conversion of arachidonic acid into prostaglandins.Two COX isoforms have been identified,named COX-1 and COX-2. The COX-1 enzyme is expressed constitutively,whereas the COX-2 enzyme is highly inducible. The changes of COX level were involved in many diseases,such as inflammation,Alzheimers Disease,cancer and atherosclereosis. COX plays an important role in drugs development and some nonsteroidal anti-inflammatory drugs (NSAIDs) target at COX-2.This review summarizes the current understanding of COX-1 and COX-2 in normal physiology and pathophysiology and the status of development in COX inhibitor.更多还原