【摘要】 目的·· :分析《中国药物依赖性杂志》10年刊登的科研论文 ,看我国药物依赖性研究状况 ,为进一步开展工作提供依据。方法·· :系统分析本刊10a刊登的科研论文。结果·· :1992年 -2001年共刊登科研论文442篇 ,其中临床研究论文206篇 ,占46.6 % ;基础研究123篇,占27.8 % ;药物滥用流行病学研究105篇 ,占23.8% ;其它8篇,占1.8 %。研究涉及的主要依赖性物质为海洛因 (153篇 ,占34.6 % )、其它阿片类 (61篇 ,占13.8% ,包括二氢埃托啡21篇 ,占4.8 % ) ;酒精 (18篇 ,占4.1 % )。基础研究主要是依赖性研究 (101/123)和一般药理学研究 (20/123)。涉及行为学研究的文章较多 (68/123);有19篇 (19/123)分子生物学研究。临床研究主要是对毒品滥用并发躯体疾病的治疗研究 (83/206) ,临床药物治疗研究 (64/206)和临床实验研究 (14/206)。药物滥用流行病学研究覆盖了20个省、直辖市、自治区 ,调查的内容主要是吸毒人群的一般情况 (69/105) ,一般人群对依赖性物质的态度、认知、使用等 (20/105) ,麻醉药品、精神药物等的使用情况 (13/105),HIV/AIDS(11/105)等。结论·· :药物依赖性研究涉及到基础、临床和流行病学3个方面。临床研究占的比重较大。研究的滥用物质主要是阿片类。已有涉及分子生物学水平的研究 ,流行病?更多还原

【Abstract】 Objective: To review drug dependence and drug abuse research in China and provide data for further research through analysis of ten-year publications in Chinese Journal of Drug Dependence. Methods: Original articles published from 1992 to 2001 in the Journal were selected and analyzed. Results:Totally 442 original articles were published , including 206 (46.6%) in clinicalresearch, 123 (27.8%) experimental studies, 105(23.8%) drug epidemiological studies and 8 (1.8% )others. The main abused drugs involved were heroin (153/442), opium (40/442), dihydroetorphine (21/442), and alcohol (18/442). Dependence potential (101 /123) and general pharmacology of detoxification agents (20/123) were the main subjects involved in experimental studies. Many articles dealt with behavior(68 /123). Some articles (19 /123)were at molecular level. Clinical studies mainly included drug abuse induced complications (83/206 ),pharmacotherapies (64/206) and clinical experimental studies(14/206). Epidemiology studies covered 20 provinces, municipalities and autonomous regions. The main subjects investigated were general situation of drug abusers (69 /105), attitude towards and knowledge about and use of drugs of general population (20/105), utilization of narcotics and psychoactive drugs (13/105), HIV/AIDS (11 /105). Conclusion: Clinical, experimental and epidemilogy studies are involved in drug dependence and drug abuse research, with clinical studies in the dominate. Opioids are the main abused substances studied. Some studies have reached molecular level. Epidemiology studies covered most of the provinces in China. However, fewer studies are conducted in regions with serious drug abuse problems. Relapse prevention and combined studies with HIV/AIDS need enhancement. The Journal revealed the general feature of the research in this field in China.更多还原