【摘要】 目的 :探讨氯硝西泮对持续性TD的临床作用。方法 :对 12例精神分裂症持续性TD患者加用小剂量氯硝西泮 ,用AIMS、TDRS、TESS和BPRS ,随访半年 ,进行前瞻性开放性研究。结果 :加服氯硝西泮前后自身对照比较 :AIMS严重度分除加药第 2周和第 12周外 ,差异均有显著性 (P <0 .0 5 ) ,4例患者 ( 3 3 .3 % )加氯硝西泮后不自主运动明显改善 ,未见反复。结论 :小剂量氯硝西泮治疗部分持续性TD患者有一定疗效 ,安全性较好更多还原

【Abstract】 Objective: To study effect of clonazepam on persistent tardive dyskinesia(TD). Method: 12 Schizophrenics who had persistent TD were treaded by adding lower doses clonazepam for 6 months.AIMS,TDRS,TESS, and BPRS were used to measure. Result: The severity scores of AIMS were declined after clonazepam treatment. They had significant difference( P<0.05 ) before and after this treatment except those in the 2nd and 12th week. In 4 cases, dyskinesia was remarkably improved and did not relapse. Conclusion: The lower dose clonazepam may be an effective and safe method for some persistent TD.更多还原