【摘要】 目的　研究 2型糖尿病微量白蛋白尿 (MAU)的危险因素。方法　对 47例 2型糖尿病合并MAU的患者和 56例 2型糖尿病非合并MAU的患者的病程、年龄、血脂、血糖、血压、空腹胰岛素 (FINS)和空腹C肽 (F -CP)水平等因素进行分析比较 ,同时将微量白蛋白排泄率 (UAER)与各指标进行相关分析和多元逐步回归分析。结果　 2型糖尿病合并微量白蛋白尿组的病程、舒张压 (DBP)、甘油三酯 (TG)、载脂蛋白B(APOB)显著高于非合并微量白蛋白尿组 ,而高密度脂蛋白 (HDL -C)则明显低于后者 ;UAER与年龄、病程、血压、空腹C肽 (F -CP)、糖化血红蛋白(HbA1C)、TG、低密度脂蛋白 (LDL -C)、APOB呈正相关 ,与HDL -C呈负相关 ;经多元逐步回归分析后得出 :UAER与HbA1C、F -CP、TG、SBP、病程、APOB呈正相关 ,与HDL -C呈负相关。结论　 2型糖尿病的病程长和以高TG、高APOB和低HDL为特征的脂代谢紊乱是糖尿病肾病的危险因素 ,高血压、HbA1C、高F -CP水平也是糖尿病的危险因子。更多还原

【Abstract】 Objective\ To study risk factors for microalbuminuria in type 2 diabetes mellitus.Methods\ The diabetic course,age,blood pressure,serum lipids,blood glucose,the fasting insulin(F-INS),the fasting C peptide(F-CP),glucosylated hemoglobin(HbA1c) and other clinical data were evaluated in 56 patients with type 2 diabetes without microalbuminuria (NMAU) and in 47 patients with type 2 diabetes with microalbuminuria (MAU).The stepwise regression analysis was used with urinary albumin excretion rate (UAER) as dependent variable.Results\ The means of the diabetic duration,diastolic pressure (DBP),hypertriglycemia,plasma apolipoprotien (APO B)in the group of MAU were significantly higher than those in NMAU group.UAER was significantly positively correlated with age,disease course,blood pressure,F-CP,HbA1C,TG,LDL-C,APOB,whereas negatively correlated with HDL-C.The stepwise regression analysis showed that the increase levels of HbA1c,F-CP,TG,systolic pressure,APOB were significantly positively correlated with UAER,rather negatively correlated with HDL-C.Conclusion\ The diabetic duration,hypertension,the dyslipidemia characterized with hypertriglycemia,high level of APOB and low level of HDL were the risk factors of type 2 diabetic nephropathy.The high level of HbA1c and F-CP were risk factors for microalbuminuria in tyep 2 diabetes mellitus.更多还原