【摘要】 根据酚酮的结构特点 ,对酚酮类化合物与半乳糖的Kenigs Knorr反应进行了研究 .探索出一种具有较高立体选择性的合成方法 ,从而制得四种具有 β 构型的单一端基异构体的酚酮半乳糖苷新化合物 .生成的新化合物不但保持了原有的生理活性 ,而且降低了毒性、提高了药效 ,为人工合成酚酮类增添新化合物的同时 ,也扩展了此类化合物的应用领域 .应用元素分析、核磁共振、红外光谱表征了它们的结构 .更多还原

【Abstract】 The Kenigs-Knorr reaction of tropolone with galactopyranosyl was studied according to the structure character of tropolone. A synthetic method of high stereoselectivity was developed, which provided four new galactopyranosides of tropolone as β-D-anomers. These compounds had not only their original physiological activity but also low toxicity.更多还原