【摘要】 以 3 羟基 2 烷基 4 (1H) 吡喃酮为原料与胺反应制备N 取代 4 (1H) 吡啶酮 ,再与亲核试剂发生氧化 -迈克尔加成反应 ,合成了相应的N 取代 6 芳硫基吡啶酮化合物 .生物活性研究结果发现 ,N 取代 6 芳硫基吡啶酮类化合物对 5 脂氧合酶具有良好的抑制作用 .更多还原

【Abstract】 N-Substituted-4(1H)-pyridinones were synthesized by the reaction of 3-hydroxy-2-alkyl-4(1H)-pyranone with amine. The resulting compounds subsequently underwent an oxidation-Michael addition with nucleophiles to afford the corresponding N-substituted-6-arylthio-4(1H)-pyridinones. The biological activity assay indicated that N-substituted-6-arylthio-4(1H)-pyridinones were of favorable inhibitory activity on 5-lipoxygenase.更多还原