【摘要】 总结了合成非对称取代脲的几种方法 ,分析了各种方法的利弊 ,介绍了非对称取代脲的主要应用 .指出直接利用一氧化碳进行硒催化的胺与硝基化合物的氧化还原羰基化反应来合成非对称取代脲的方法是比较有发展前景的方法 ,并对硒催化的氧化还原羰基化反应作了较为详细的介绍更多还原

【Abstract】 Unsymmetrically substituted ureas are widely used in agriculture, medicine and biology. Their main synthetic methods are summarized and analyzed in this article. According to their advantages and disadvantages, it is pointed out that the catalytic method of directly using carbon monoxide is more promising and efficient for the synthesis of unsymmetrical ureas. Combined with our own research work, the substituted reaction of ureas and amines, as well as selenium-catalyzed oxidative carbonylation of amines and reductive carbonylation of nitro compounds with carbon monoxide as a carbonyl reagent are recommended in detail. Through one-step or two-step, unsymmetrical ureas can be obtained easily and conveniently.更多还原