【摘要】 为赋予天然产物以新颖和特定的性质 ,往往需要对其进行结构修饰 .结构修饰可以通过化学法、微生物法和酶法实现 .其中酶法由于条件温和 ,化学、区域和立体选择性高 ,操作简便 ,环境友好等特点而发展非常迅速 .本文介绍了糖和糖苷、甾族化合物、β 内酰胺抗生素、氨基酸和多糖类等的酶法结构修饰 ,并指出组合酶催化将成为现有组合化学方法的重要补充更多还原

【Abstract】 Directional structural modification of natural products is needed for developing novel compounds of specific properties. Three different approaches are known: chemical, microbial and enzymatic modification. Among them, enzymatic approach has been developed rapidly due to the following advantages: mild reaction conditions, high chemo-, stereo- and regio-selectivity, simple manipulation, and its environment benign nature. This paper briefly describes the enzymatic structural modification of some natural products including sugars and glycosides, steroids, β-lactam antibiotics, amino acids and peptides, and suggests that combinatorial enzymatic catalysis will be a powerful complement to the existing combinatorial methods.更多还原