【摘要】 马立克氏病 (MD)是严重危害养鸡业发展的急性传染病。从 1996年起 ,采用血型基因检测和后裔马立克氏病病毒 (MDV)攻击选留强抗性亲本途径开展了MD抗性选育实验。结果表明 :(1)亲本成鸡 4个世代No 6 14血型基因检测阳性率逐代上升 ,由F0 的 6 8 8%、F1的 77 3%、F2 的 81 8%到F3 的 90 5 %。 (2 )F2 ～F4雏鸡 10日龄MDV攻击 ,6 0日龄死亡率 ,亲本对No 6 14抗血清呈阳性反应的实验组 3个世代分别是 2 5 8%、6 9 2 %和 2 9 4 % ;亲本对No 6 14抗血清呈阴性反应的对照组相应是 30 6 %、81 0 %和 5 2 9% ;实验组显著低于对照组 (P <0 0 1或P <0 0 5 )。 (3)实验期间F2 ～F4雏鸡 9个内脏器官组织肿瘤病变率 ,实验组 3个世代分别是 87 6 %、83 3%和 5 8 8% ;对照组相应为 88 1%、84 5 %和 70 6 % ;两者比较除个别世代、个别器官实验组低于对照组 (P <0 0 5 )外 ,多数没有显著差异 (P >0 0 5 )。并对实验结果及MD抗性的遗传控制进行了讨论更多还原

【Abstract】 The Marek’s Disease is an acute infectious disease in poultry production. The selecting experiment through blood group gene inspection of adult parents and attack test by using of Marek’s Disease virus (MDV) for offspring chicks was carried out. The results showed as follows:(1)The rates of positive reaction by No.614 blood group gene inspection of adult parents in four generations were increased due to generation increase, as F 0 68.8%, F 1 77.3%, F 2 81.8% and F 3 90.5%. (2)In the attack test by using of MDV at 10 days of age of chicks the mortalities of the experimental group at 60 days of age of chicks whose parents have positive reaction by No.614 blood group reagent detect in F 2～F 4 generations were 25.8%, 69.2% and 29.4% respectively, while the mortalities of the control group at same age of chicks whose parents have negative reaction were 30.6%,81.0% and 52.9% respectively. These differences of mortality were significant ( P <0.01 or P <0.05). (3) The rates of pathological change of 9 viscera tumor of the experimental group chicks in F 2～F 4 generations were 87.6%,83.3% and 58.8% respectively, while chicks in the control group were 88.1%,84.5% and 70.6% respectively. Except individual generation and viscera,these differences between the experimental group and the control group were almost not significant ( P >0.05). The experimental results and genetic control of resistance to Marek’s Disease are discussed in this paper. The new strain of chicken resistant to Marek’s Disease will be bred.更多还原