【摘要】 目的　研究黄芩苷对大鼠缺血再灌注损伤的保护作用。方法　结扎大鼠左冠脉前降支 4 0min再灌注 12 0min ,观察黄芩苷对心肌梗死后大鼠心功能、心肌梗死面积和乳酸脱氢酶 (LDH)活性、丙二醛 (MDA)含量、超氧化物歧化酶(SOD)活性等的影响。结果　结扎冠脉前 5min给黄芩苷10～ 4 0mg·kg-1能改善心肌梗死后大鼠的心功能、减少心肌梗死面积 (9%～ 30 % ) ,并能减少梗死后心肌MDA含量、提高梗死后心肌SOD、LDH的活性。结论　黄芩苷对大鼠缺血再灌注的心肌损伤有保护作用更多还原

【Abstract】 AIM To study the protective and antiperoxidative effects of baicalin on myocardial ischemia. METHODS The rat anterior decenging branch of left coronary artery was occluded for 40 min and reperfusion for 120 min. Hemodynamics (LVP, LV d p /d t ) and electrocardiogram (ECG, lead Ⅱ) monitored continuously with polygraph,then the myocardium were taken to assay lactate dehydrogenase(LDH), malondialdehyde (MDA) contents and superoxide dismatase (SOD). RESULTS Baicalin 10 or 40 mg·kg -1 iv depressed changes in LDH, MDA and SOD in myocardium after ischemia for 40 min and reperfusion for 120 min in rats. Baicalin 10 and 40 mg·kg -1 iv markedly improved the ±d p /d t max (kPa·s -1 ), LVSP in rat after ischemia for 40 min and reperfusion. CONCLUSION Baicalin possesses a protective effect against myocardial ischemia via attenuating lipid peroxidation.更多还原