【摘要】 目的　探讨循环免疫复合物 (CIC)、补体溶血总活性 (CH5 0 )、补体膜攻击复合体 (SC5b - 9)、抗核抗体(ANA)和抗双链DNA(AdsDNA)抗体在肾炎和肾病综合征患者病变中的临床意义。方法　用沉淀法、溶血法、夹心ELISA法和斑点免疫金银染色技术 (Dot-IGSS) 4种方法分别对 4 5份正常人血清、5 6份慢性肾炎综合征和 4 2份肾病综合征患者的血清进行检测。结果　SC5b - 9升高检出率最高 ,敏感性显著高于CH5 0 ;慢性肾炎综合征患者ANA、AdsDNA阳性率显著高于肾病综合征患者。结论　检测上述几种免疫学指标对于慢性肾炎或肾病综合征的病情判断及鉴别诊断均有一定的价值更多还原

【Abstract】 Objective To study the clinical significance of 5 immunologic parameters in patients with nephritis or nephrotic syndrome. Methods 143 blood specimens from 45 normal controls, 56 nephritis patients and 42 patients with nephrotic syndrome were studied to determine the contents of SC5b-9, CIC and CH50 and the titers of ANA and AdsDNA antibodies by using PEG precipitation reaction, hemolytic assay, sandwich ELISA and Dot-IGSS respectively. Results The detectability rate of SC5b-9 was the highest among these parameters and the sensitivity of the test for SC5b-9 was higher than that for CH50. Moreover, the titers of ANA and AdsDNA antibodies in patients with nephritis syndrome were higher than in those with nephrotic syndrome. Conclusion The parameters mentioned above are of certain value in helping understand the pathologic changes and differentiate nephritis from nephrotic syndrome.更多还原