【摘要】 目的 :观察利培酮对难治性精神分裂症病人的疗效。方法 :10 6例难治性精神分裂症病人给利培酮 ,开始 1mg·d- 1,2wk内加至 4～ 6mg·d- 1,分 2次服 ,共用 12wk ,用BPRS ,SANS ,SDSS ,CGI和TESS量表评定 ,观察其疗效和不良反应。结果 :治疗后经上述量表评定利培酮治疗难治性精神分裂症有效率 34%。不良反应轻 ,以震颤、急性肌张力增高、静坐不能为主。结论 :利培酮治疗难治性精神分裂症较文献报道的传统的抗精神病药的疗效要高更多还原

【Abstract】 AIM: To observe the efficacy of risperidone in treating patients with refractory schizophrenia. METHODS: One hundred and six patients with refractory schizophrenia were treated with risperidone(4 6 mg·d -1 ) for 12 wk, and the efficacy and adverse reactions were assessed with BPRS,SANS,SDSS,CGI and TESS. RESULTS: The effective rate of risperidone in treating refractory schizophrenia was 34 %. The adverse reactions such as tremor, acute dystonia, akathisia were slight. CONCLUSION: The efficacy of risperidone which is a new typical antipsychotics is superior than that of classical antipsychotics.更多还原