【摘要】 目的 :观察托吡酯加用治疗多种类型癫痫发作的临床疗效。方法 :2 18名癫痫病人 ,均为用过各种抗癫痫药物治疗效果不佳的难治性癫痫 ;采用逐渐加量法 ,加量期 8wk ,托吡酯开始剂量为 2 5mg·d- 1,目标剂量为 2 0 0mg·d- 1,观察 12wk后进入延长期。结果 :治疗后 ,2 6例病人 (12 .3% )发作完全消失 ,5 9例 (2 8.0 % )发作减少≥ 75 % ;10 7例(5 0 .7% )发作减少≥ 5 0 %～ <75 % ;19例(9 .0 % )无效。 5例 (2 .3% )因严重不良反应而中断治疗。 2例失访 (原因不明 )。结论 :托吡酯是一种非常有效的新型抗癫痫药物 ,值得临床推广使用更多还原

【Abstract】 AIM: To investigate the efficacy of topiramate (TPM) in the add on treatment of various types of refractory epilepsy seizures. METHODS: Two hundred and eighteen patients with refractory epilepsy were all treated with antiepileptic drugs (AEDs). The method of desage adding was used. The dosage adding period was 8 wk, 25 mg·d -1 of TPM at the begining and the target dosage was 200 mg·d -1 , After 12 wk of observation, TPM treatment was prolonged. RESULTS: After TPM treatment 26 patients (12.3 %) became seizure free, 59 patients (28.0 %) were ≥75 % seizure reduction, 107 patients (50.7 %) were ≥50 % seizure reduction, 19 patients (9.0 %) remained unacceptable seizure control. Five patients (2.3 %) were discontinue treatment with adverse reactrons, two patients were lost contact with reason not clear. CONCLUSION: TPM is a very effective new AED and worthy of clnical application and dissemination.更多还原