【摘要】 综述选择性 5 羟色胺再摄取抑制药 (SS RIs)与性功能的关系。SSRIs引起的性功能障碍中 ,最多见为射精延迟、性高潮缺乏或延迟 ,其次为性欲和唤醒困难。SSRIs与性功能的关系不应该认为是完全负面的 ,一些研究显示其有助于改善男性的早泄。SSRIs与性功能的关系可能与 5 羟色胺和多巴胺再摄取机制、催乳素高分泌、抗胆碱能作用、抑制氧化亚氮合成酶及累积倾向有关。已有多种措施用于克服SSRIs所致性功能障碍 ,西地那非可能是其中最为有效的药物治疗手段更多还原

【Abstract】 This article reviews current evidence regarding sexual adverse reaction of selective serotonin reuptake inhibitors (SSRIs). Among the sexual adverse reactions, the most commonly associated with SSRIs are delayed ejaculation and absent or delayed orgasm. Sexual desire (libido) and arousal difficulties are also frequently reported. Sexual adverse reaction of SSRIs should not be viewed as entirely negative; some studies have shown that SSRIs can improve premature ejaculation in men. The effects of SSRIs on sexual functioning seem related to serotonin and dopamine reuptake mechanisms, induction of prolactin release, anticholinergic effects, inhibition of nitrous oxide synthetase, and propensity for accumulation over time. A variety of strategies have been reported in the management of SSRIs induced sexual dysfunction, however, sildenafil may represent a most efficacious approach to this problem.更多还原