【摘要】 目的:探讨血小板计数与类风湿关节炎(RA)病情活动的相关性。方法:回顾性分析111例RA病例的临床资料,根据血小板计数分为血小板增高组(血小板超过300×109/L)与血小板正常组(血小板100×109/L～300×109/L),比较两组的病程、临床表现、实验室指标,并观察分析两组治疗后的病情缓解情况。结果:血小板增高组的发热、晨僵、压痛关节数、肿胀关节数、白细胞、血红蛋白、C反应蛋白、ESR、类风湿因子、IgG、IgA、IgM、C3与血小板正常组比较均有统计学差异,血小板计数增高与RA病情的活动密切相关,但与RA的病程无关。血小板增高组治疗1个月后的病情缓解率低于血小板正常组(P<0.01)。结论:除外药物不良反应的影响,血小板计数可作为评价RA病情活动和疗效的简便有效的指标之一。血小板超过450×109/L者,提示病情严重,宜加强免疫干预治疗。更多还原

【Abstract】 Objective:To investigate the relationship between peripheral platelet count (PLT)and rheumatic arthritis(RA)disease activity.Methods :Clinical data of 111patients with RA were analyzed retrospectively.Patients were divided into two groups by PLT:high PLT group(PLT>300×10 9 /L)and normal PLT group(PLT≥100×10 9 /L and≤300×10 9 /L).Clinical manifesta-tion,laboratory examination,and remission of disease were compared between the two groups.Results:There were significant dif-ferences in fever,morning stiffness,number of tender joints,number of swollen joints,hemoglobin level,erythrocyte sedimentation rate,C-reactive protein,rheumatoid factor,immunoglobulin(Ig)G,IgA,IgM and C3between the two groups.Increased PLT count was closely correlated with RA disease activity.But there was no re lationship between PLT count and cou rse of RA.Remission rate was lower in high PLT group than t hat of normal PLT group after treatme nt for one month(P<0.01).Conclusion:PLT count can be used as an effective criterion in evaluating RA disease activity if the influence of drugs can be excluded.PLT higher than450×10 9 /L suggests more severe RA which need s more potent immunosuppressive therapy.[更多还原