【摘要】 为探讨慢性粒细胞白血病临床分期与端粒酶活性的关系,采用聚合酶键反应-酶联免疫吸附法(PCR-ELISA)测定骨髓细胞端粒酶活性。结果发现,正常骨髓细胞端粒酶活性低,慢性粒细胞白血病各期端粒酶活性均高于正常骨髓组(P<0.05),加速期和急变期高于慢性期(P<0.05),但加速期和急变期两组无差别。结论提示,端粒酶活性可做为慢性粒细胞白血病分期和判断预后的有用指标。更多还原

【Abstract】 To study the telomerase activity change in patients with CML different phases,telomerase PCR-ELISA method was used.Results showed that telomerase activity of normal bone marrow cells was low.The telomerase activity in CML at any phase was higher than that in normal bone marrow ( P < 0.05).The telomerase activity in accelerated and acute transformation phases was higher than that in chronic phase ( F < 0.05),but there was no significant difference between accelerated phase and acute transformation phase.It was concluded that telomerase activity could be used as an useful marker for evaluating development of course and curative effect of CML.更多还原