【摘要】 目的 :对高血压大鼠不同昼夜时点给药后降压效果进行比较。方法 :12只雄性SD大鼠分为三组 ,在口服NG-硝基 -L -精氨酸甲酯 (NG-nitro -L -arginine -methlester,L -NAME)复制大鼠高血压模型的基础上 ,对高血压大鼠进行 2 4小时动态血压监测 ,应用余弦软件分析血压的节律情况 ,计算出血压的峰值、中值和谷值所对应的时间点 ,分别于各时点前三个小时给予依那普利 (10mg kg·d- 1 ) ,连续 2周。结果 :依那普利能够降低L -NAME引起的高血压 ;峰值前、中值前和谷值前给予依那普利后 ,血压分别下降 12 .2 %、8.2 %和 8.3%。结论 :在抗高血压治疗中 ,峰值前给药能更有效地降低血压。更多还原

【Abstract】 Objective and Method To study the effect of enalapril on hypertension rats in different circadian time, 12male SD rats were randomly divided into 3 groups. On the model of rat hypertension induced by N G-nitro-L-arginine-methlester(L-NMAE), The blood pressure of each rat was measured for 24 hours. Then the data of blood pressure were analyzed by cosinor software to determine the circadian time of peak, mean and vallecula, just 3 hours ahead of the time, enalapril(10mg/kg·d -1 ) was given to each rat for 2 weeks.Result Enalapril can low the rat hypertension induced by L-NAME; The blood pressure decrease by 12.2%, 8.2% and 8.3% respectively.Conclusion The administration before peak of enalapril produce greater decrease of BP than the administration before mean and vallecua.更多还原