【摘要】 嘧啶类化合物与金属离子形成的配合物作为动物饲料添加剂,不仅增强原药物的活性、延长持效期和半衰期,而且还能降低毒性。研究表明[1]:Pt和Pd的嘧啶类配合物具有很好的抗癌效果,但对人体特别是肾脏等器官的毒性大;若用人体必需的微量元素Cu,Zn,Co,Ni等代替Pt或Pd,则可能降低毒性。更多还原

【Abstract】 2Amino4, 6ethyloxypyrimidine (EMP) was synthesized using benzyltriethylammonium (BTEA) as a catalyst in yield of 87.5%. A solid complex of the Ni(Ⅱ) with it was obtained by reacting AMP with NiCl2 in ethanol. The composition of the complex was determinated by chemical analysis and microanalyses as Ni(EMP)2·Cl2. The structure of the complex and sp3d2 of the hybridization type of Ni2+ were characterized by I R, XPS and 1HNMR.更多还原