【摘要】 目的观察复方丹参对脊髓继发性损伤的神经保护作用。方法Wistar大鼠 5 4只 ,以改良Allen氏法制备脊髓打击伤模型 ,随机分为三组。测定不同药物处理后 8和 2 4小时脊髓组织SOD活性和MDA浓度以及血液流变学改变 ;术后 2 ,4周联合行为学评分 (CBS)观察实验动物的神经功能恢复情况。结果复方丹参处理后 ,脊髓组织MDA浓度明显低于各时相点对照组 ,SOD活性显著升高 (P <0 .0 1 ) ,与甲基强的松龙治疗组无明显差异 (P >0 .0 5 ) ,血液流变学指标也有所改善 ,CBS评分明显增加 (P <0 .0 1 )。结论复方丹参治疗可以缓解脊髓损伤后的脂质过氧化反应 ,改善微循环 ,从而发挥脊髓保护作用。更多还原

【Abstract】 Objective To study the protective effect of salvia miltiorrhiza(SM) on the injuried spinal cord in Wistar rats.Methods 54 adult rats were made as spinal cord contusion models at the T9 segment and divided into three groups:simple spinal cord injury(SCI)group,SCI with methylprednisolon(MP) treatment group and SCI with SM treatment group.The activity of SOD and the concentration of MDA of the injuried spinal cord tissue were measured at 8 and 24h after reagents were intraperitoneally injected.Blood rheology were evaluated by viscometer at the same time.Functional status was assessed by the modified combined behavioral score(CBS) at 2 and 4 weeks after operation respectively.Results In the group treated with SM, the activity of SOD was elevated and level of MDA was reduced significantly(P<0.01),moreover,the impaired microcirculation was alleviated and CBS of rats were increased markedly as well.Conclusion Treatment with Salvia miltiorrhiza can alleviate the lipid peroxidation and microcirculative damage resulted from secondary injury and thus show a promising future for treatment of SCI.更多还原