【摘要】 目的:了解妊娠肝内胆汁淤积症 (ICP)孕妇体内雌激素水平的变化对肝酶的影响。 方法 :选取 ICP孕妇 34例为研究组 ,另选同期入院正常孕妇 34例为对照组。所有孕妇均在分娩前 30 m in内取肘静脉血 3m l,测定血清内雌三醇 (E3)水平。随机选择 ICP组和对照组 2 0例在分娩后收集胎盘组织 ,用免疫组化法测定胎盘组织中雌激素受体 (ER)的表达强度。同时分析比较两组肝酶的临床资料。结果 :ICP组血清雌激素水平、胎盘组织中 ER的表达率均高于正常对照组 (P<0 .0 5 ) ,ICP组比对照组肝酶明显升高 (P>0 .0 5 )。 结论 :ICP孕妇体内雌激素水平升高可影响孕妇肝脏的功能更多还原

【Abstract】 Objective: TO investigate the effect of estrogen on maternal hepatic function in intrahepatic cholestasis of pregnancy(ICP). Methods: 34 women with ICP as study group and 34 normal pregnant women as control group were enrolled in study. All elbow vein blood were drawn within half an hour before delivery. The level of E\-3 were detected. Twenty cases of two groups respectively were measured for ER of placenta tissue by immunohistochemical method, and the data of hepatic function were studied. Results: The level of E\-3 and positive express rate of ER on placenta in ICP group was increased significantly more than those in control group (P<0.05) and hepatic enzymatic level in ICP group was also higher than those in control group. Conclusion: The higher level of E\-3 and the intensive expression of ER on the placenta may play an important role to hepatic function in pregnancy women with ICP.更多还原