【摘要】 目的 :采用开放对比研究比较克拉霉素 (clarithromycin)与阿奇霉素 (Azithromycin)以评价克拉霉素治疗老年下呼吸道感染的疗效及安全性 .选择未用过抗生素治疗或虽用抗生素但无效的老年下呼吸道感染。方法 :70例 ,随机分成两组 ,分别为治疗组 (克拉霉素组 )或对照组 (阿奇霉素组 ) ,治疗组 2 5 0mg ,每日 2次口服 ,疗程 7- 14天 ,对照组 5 0 0mg ,每日 1次口服 ,疗程 7天。结果 :显示治疗组与对照组痊愈率分别为 4 5 .71%与 5 5 .71% ,总有效率为 91.4 3%与 94 .2 9% ,细菌清除率为 95 %与96 % ,不良反应发生率为 8.6 %与 5 .7%。两组比较差异均无显著性 (P >0 .0 5 )。结论 :提示在治疗轻 ,中度老年下呼吸道感染克拉霉素与阿奇霉素相仿 ,疗效好 ,不良反应少 ,对老年下呼吸道感染有效且安全更多还原

【Abstract】 OBJECTIVE:To evaluate the efficacy and safety of clarithomycin and azithromycin in treating elder patients of lower respiratory tract infection. METHOD:70 cases of lower respiratory tract infection beyond 60 years old were divided into two group randomly, The control group were by azithromycin (500mg po qd 7d ). The experimental group were by clarithromycin ( 250mg po Bid 7-14d).RESULTS:The overall efficacy rates of clarithromycin and azithromycin were 91.43% and 94.29%, bacteria elimination rates were 95% and 96%, adverse events were 8.6% and 5.7%. No significant differences were noted between the two groups. All the adverse events were mild and disappeared after withdrawal of drug. CONCLUSION:The study shows that clathromycin is well tolerated and offective in treating lower respiratory tract infectios.更多还原