【摘要】 目的 :探讨克拉霉素 (CAM)对急性肺损伤 (ALI)的预防作用及其作用机理。方法 :采用油酸 (OA)型大鼠ALI模型 ,将实验动物随机分为对照组、OA致伤组 (OA组 )、CAM预防组 (CAM组 )和地塞米松预防组 (DX组 ) ,每组 10只。观察比较各实验组OA致伤后动脉血氧分压 (PaO2 )、肺泡灌洗液 (BALF)中中性多形核白细胞 (PMN)总数 ,肿瘤坏死因子 (TNFα)水平、肺脏组织病理学改变和肺组织湿 /干 (W/D)比值的变化。结果 :CAM预防组PaO2 下降的时间晚于DX组 ,致伤 8h后低氧血症的严重程度较DX组明显减轻 ;OA致伤后 2 4h ,CAM组BALF中的PMN计数、TNFα水平、W/D比值均明显低于DX组 ;肺脏组织损伤程度也明显减轻。结论 :CAM对油酸型急性肺损伤具有一定的预防作用 ,其机理可能与抑制PMN在肺内聚集和有关细胞释放TNFα有关更多还原

【Abstract】 Objective:To study preventive effect of clarithromycin (CAM) on acute lung injury (ALI)induced by oleic acid.Methods:The rats were randomly divided into 4 groups: oleic acid group (OA group), CAM preventive group (CAM group), dexamethasone preventive group (DX group) and control group. PaO 2, polymorphonuclear neutrophilic leukocyte (PMN) counts, concentration of TNFα in bronchoalveolar lavage fluid (BALF), histologic evaluation of lung and content of lung water were compared in different groups.Results:Compared with that of DX group, PMN counts, concentration of TNFα in BALF and content of lung water in CAM group were markedly decreased,PaO 2 and histologic changes of lung were slighter.Conclusion:CAM may has preventive effects on ALI induced by oleic acid, which is possibly associated with inhibited PMN aggregation and downregulation of TNFα.更多还原