【摘要】 目的　观察瘦素受体在SD大鼠中枢神经系统的组织学定位。方法　采用高度特异的抗瘦素受体血清 ,用免疫组织化学ABC法观察瘦素受体在大鼠脑的分布。结果　在SD大鼠的前脑 (包括嗅球 )、皮层Ⅳ、Ⅴ层、海马、下丘脑、杏仁核、丘脑等可以观察到瘦素受体免疫反应阳性物质 (LR IR) ,其中下丘脑弓状核、视上核、视交叉上核、杏仁基底外侧核、孤束核有较强的LR IR ,而下丘脑外侧视前区、杏仁中央核有较弱的LR IR。结论　瘦素受体广泛存在于大鼠中枢神经系统 ,包括下丘脑、杏仁核等与味觉和摄食调节密切相关的核团更多还原

【Abstract】 Objective To observe the location of leptin receptors (LR) in the brain of SD rats.Methods Immunohistochemical ABC method was used with high specify goat antiserum against LR.Results LR immunoreactivities (LR IR) were observed in the hypothalamus, hippocampus, amygdala,the choroid plexus, cerebral cortex and thalmus. In the supraoptic nucleus, arcuate nucleus, suprachiasmatic nucleus and basallateral nucleus of amygdala, strongly LR immunoreative neurons were found present. Weaker LR IR neurons were found in the lateral preoptic nucleus of hypothalamus and amygdaloid central nucleus.Conclusion LR is widely found in the central nervous system of rats, including hypothalamus and amygdala, which are closely related to feeding and taste.更多还原