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双嘧达莫的协同荧光增敏光谱分析法研究
Study on the Enhanced Fluorescence Spectrum Analysis Method of Dipyridamole
【摘要】 以荧光光谱法研究了三羟甲基氨基甲烷 盐酸 (Tris HCl)缓冲溶液和溴化十六烷基三甲铵 (CTMAB)、Tris HCl缓冲溶液和β 环糊精 (β CD)两体系对双嘧达莫的协同荧光增敏作用 ,提出了在此条件下用协同荧光增敏光谱分析法测定双嘧达莫含量的新方法 本法灵敏度高 ,检测限低 (9.2 0× 10 -9mol/L) ,在 7.92 6× 10 -8~ 2 .378× 10 -6mol/L范围内荧光强度与双嘧达莫的浓度呈良好线性关系 .
【Abstract】 The spectral properties of dipyridamole were studied in the presence of CTMAB,β-CD by the fluorescence spectroanalysis.It was found that the fluorescence intensity of dipyridamole was greatly enhanced in the systems of CTMAB-Tris andβ-CD-Tris.A new fluorescence spectroanalysis method was established for determining dipyridamole in aqueous solution with high selectivity and specificity.
【关键词】 双嘧达莫;
荧光光谱法;
药物分析;
【Key words】 dipyridamole; enhanced fluorescence spectroanalysis; pharmaceutical analysis;
【Key words】 dipyridamole; enhanced fluorescence spectroanalysis; pharmaceutical analysis;
【基金】 湖北省教育厅科学研究资助项目 ( 2 0 0 1A410 0 5 )
- 【文献出处】 武汉大学学报(理学版) ,Wuhan University Journal(Natural Science Edition) , 编辑部邮箱 ,2002年06期
- 【分类号】O657.39
- 【被引频次】10
- 【下载频次】102