【摘要】 目的　了解原发性肝癌、代偿期肝硬化、失代偿期肝硬化患者血清肿瘤坏死因子 α(TNF α)、白细胞介素 2 (IL 2 )、可溶性白细胞介素 2受体 (sIL 2R)水平的变化 ,探讨其临床意义。方法　原发性肝癌 33例 ,肝炎后肝硬化 6 0例。分为肝癌组 33例 ,肝硬化代偿期组 30例 ,肝硬化失代偿期组 30例。采用双抗体夹心酶联免疫法检测血清TNF α、IL 2、sIL 2R水平。肝癌组患者追踪 2月至 2年 ,观察其变化情况。结果　 1 原发性肝癌组血清TNF α、sIL 2R水平明显高于各期肝炎后肝硬化组 ,而血清IL 2水平较各期肝炎后肝硬化组显著降低。 2 肝硬化失代偿期组血清TNF α、sIL 2R水平明显高于肝硬化代偿期组 ,而肝硬化失代偿期组IL 2水平低于肝硬化代偿期组。 3 原发性肝癌组经有效手术治疗及导管化疗者血清TNF α及sIL 2R水平较治疗前明显降低 ,IL 2则较前升高 ,而未经有效治疗或治疗时已是晚期者TNF α及sIL 2R水平逐渐升高 ,IL 2则逐渐降低。结论　本文提示原发性肝癌及肝炎后肝硬化与TNF α、IL 2及sIL 2R有密切相关性。TNF α、IL 2及sIL 2R水平的变化有助于了解肝硬化的进展情况 ,早期发现恶性肿瘤并决定治疗的预后。更多还原

【Abstract】 Aim To investigate the levels of TNF-α,IL-2 and sIL-2 in serum in the patients with primary hepatic carcinoma and liver cirrhosis and discuss their clinical significance.Methods The levels of TNF-α,IL-2 and sIL-2 in serum were evaluated in 33 patients with primary hepatic carcinoma and 60 patients with liver cirrhosis by an enzymelinked immunosorbent assay (ELISA).Results The levels of TNF-α and sIL-2R were significantly higher and the level of IL-2 was lower in patients with primary hepatic carcinoma than that in liver cirrhosis respectively.The levels of TNF-α and sIL-2 were higher and the level of IL-2 was lower in decompensated cirrhotic patients than that in compensated ones respectively.The levels of TNF-α and sIL-2R got significantly lower and IL-2 higher after treatment.Conclusions The levels of TNF-α,IL-2 and sIL-2R are correlated with the primary hepatic carcinoma and cirrhosis.The detection of TNF-α,IL-2 and sIL-2R is conducive to the early diagnosis of carcinoma.更多还原