【摘要】 目的　研究原发性肝细胞癌P170 的表达及临床意义。方法　采用免疫组化SABC法 ,用小鼠抗人P170 单克隆抗体JSB1,对随机选择的 4 6例原发性肝细胞癌手术后石蜡包埋标本进行染色 ,同时设立阳性及阴性对照组。结果　原发性肝细胞癌的P170 阳性表达率为 6 0 7% ,化疗后达 88 9% ,P170 阳性表达组原发性肝癌的生存时间低于阴性表达组。结论　肝脏是原发性耐药器官 ,化疗可以诱发耐药的产生 ,P170 的表达是原发性肝细胞癌的一个预后指标更多还原

【Abstract】 Objective: To study the expression of P 170 in patients with primary hapatocellular carcinoma (PHC) and explore its clinical value Methods: Forty six parafin embedded specimens from patients with PHC were investigated by immunohistochemistry (SABC) after operation, through the use of anti-P 170 monoclonal antibody (JSB 1) Each process included the positive and the negative control Results: The positive rate of P 170 in PHC was 60 7%, higher in the chemotherapy group than that in the non chemotherapy, which is related to prognosis Conclusion: The liver is an organ of primary resistance, and chemotherapy can induce MDR The expression of P 170 is one of the useful indexes of prognosis in PHC更多还原