【摘要】 目的:研究糖化血红蛋白(GHb)、尿微量白蛋白(U-mAlb)与2型糖尿病肾损害的关系。方法:对受试者用高压液相法测定GHb,用免疫比浊法测定U-mAlb,用叶菲氏法测定尿肌酐(Cr),计算U-mAlb比值(mg/gCr)。结果:2型糖尿病肾损害者的GHb、U-mAlb均比健康者有显著性增高(P<0.01),并且两者呈正相关(P<0.01)。结论:GHb与U-mAlb值越高,2型糖尿病患者的肾损害程度越严重。更多还原

【Abstract】 Objective: To probe the relationship between levels of glycosylated hemoglobin (GHb) and urinary microalbumm (U-mAlb) and nephropathies in non-insulin dependent diabetic (NIDDM) patients. Methods: The levels of GHb, U-mAlb and urinary creatine were detected by the HPLC, immunoturbidimetry or Jaffe methods successively. The results of U-mAlb (mg/gCr) were calculated. Results: The levels of GHb and U-mAlb in NIDDM patiens with nephropathy were significantly higher than those in controls (P < 0.01) . The values of GHb were positively associated with the values of U-mAlb (P < 0.01). Conclusion: The values of GHb and U-mAlb were higher, the nephropathies in NIDDM patients were more dangerous.更多还原