【摘要】 目的 :为中药抗衰益智的复方对扣带回神经元的干预作用提供形态学资料。方法 :以电镜形态学观察 ,探讨七宝美髯丹对老龄小鼠 (15月龄 )扣带回神经元超微结构的影响。结果 :与老年组比较 ,参七汤组神经元脂褐素含量减少 ,细胞膜、核膜及线粒体结构清晰 ,含丰富的核糖体与粗面内质网。老年对照组粗面内质网脱颗粒 ,胞浆聚集 ,脂褐素电子密度增大 ,核糖体与粗面内质网减少 ,神经元与线粒体平均密度降低 ,线粒体平均体积明显增加且肿胀 ,甚至空泡化。结论 :推测线粒体在衰老退行性变时 ,其代偿机制可能发挥重要作用。衰老能引起老龄小鼠扣带回超微结构异常 ,七宝美髯丹对此有一定的防治作用更多还原

【Abstract】 Objective:To explore the effect of Qibaomeirandan on the ultrastructure changes of gyrus cinguli area in aged (15month) mice.Methods:structural changes in gyrus cinguli area were observed by electron microscopy.Results:The contents of lipofuscin in the neurons of region of the experiment group was reduced as compared with that of the old group.The Qibaomeirandan treatment group,the normal membrane and the structure of the mitochondrion was clearly seen in the the mice hippocampus neuron,the ridges of the mitochondrion could clearly be seen,the rich rough endoplasmic reticulim and ribosome’s,and large amount of clear synaptic vesicles could be seen either.The aged control showed depolymentation of ribosome,accumulation of lipid droplet and lipofuscin in cytoplasm,and condensation of chromatin.in the meantime,the average density of neurons in the gyrus cinguli area became shrinkage with the aging under the electron microscopy,the decrease in the number of ribosome’s and rough endoplasmic reticulum was in the same condition as well.There were obviously increased and swelled mitochondrion with vacillation,Increased electron density.But the mitochondrion average volume increased apparently swelled with aging may be the compensation mechanism play the most part in the mitochondrion degeneration.Conclusion:Aging can cause microstructure abnormalities in the mice gyrus cinguli and qibaomeirandan could prevent this abnormal structure formation.更多还原