【摘要】 为探讨丹参对自发性高血压大鼠 (SHR)心肌纤维化的作用及其可能机制 ,以 WKY大鼠为阴性对照 ,SHR大鼠为 SHR阳性对照 ,观察丹参对 SHR收缩压、胶原含量及心脏左心室醛固酮 (AL D)、 NO、超氧化物歧化酶(SOD)含量影响。结果显示 :丹参组除收缩压 (SBP)明显高于 WKY组与 SHR组无明显区别外 ,左室 I、 型胶原及AL D含量明显低于 SHR组 ,而明显高于 WKY组 ;NO、 SOD含量则明显高于 SHR组 ,但仍明显低于 WKY组 (P<0 .0 5 )。结果提示 :丹参具有预防和逆转自发性高血压大鼠心肌纤维化作用 ,其机制可能与抑制胶原合成 ,促进心脏局部胶原分解、抑制心肌局部醛固酮生成、改善心肌血液供应、调节氧自由基代谢等多方面的作用有关。更多还原

【Abstract】 To investigate the preventive and reversal effects of Salvia Miltiorrhiza Bge (SMB) on myocardial fibrosis and its possible mechanisms in spontaneously hypertensive rats (SHR), normal Wistar kyoto (WKY) rats were used as negative control and SHR served as positive control. The influence of SMB on systolic pressure (SBP), left ventricular morphology, collagen content as well as concentration of cardiac ALD and NO and SOD was observed. The results showed that the systolic blood pressure in the SMB group was almost the same as that in the SHR, but collagen type Ⅰ and Ⅲ contents in the left ventricle, the ratio of type Ⅰ/type Ⅲ and ALD were lower than those in the SHR rats, still higher than those in the WKY rats, and NO and SOD levels were higher than in the SHR , still lower than in the WKY rats. It was indicated that SMB can prevent and reverse myocardial fibrosis probably by decreasing cardiac tissue collagen syntheses and ALD level, increasing cardiac tissue collagen discompose and NO and SOD levels.更多还原