【摘要】 目的 :探讨炎性细胞因子[肿瘤坏死因子 -α(TNF -α) ,白细胞介素 -1β(IL -1β)和白细胞介素 -6(IL -6)]在SIRS期对MODS早期诊断的应用。方法 :应用酶联免疫法测定30例危重病患者SIRS早期TNF -α、IL -1β及IL -6的动态变化 ,比较MODS组与非MODS组及正常对照组的TNF -α、IL -1β及IL -6的变化。结果 :30例患者血浆TNF -α、IL -1β及IL -6水平均明显升高 ,较正常对照组差异显著 (P均<0.01) ,MODS组与非MODS组差异显著 (P<0.01和P<0.05)。结论 :细胞因子参与了MODS的发生发展 ;SIRS期血中TNF -α、IL -1β及IL -6水平对MODS的早期诊断有十分重要的意义更多还原

【Abstract】 Objective: To investigate the value of inflammatory cytokines in patients with systemic inflammatory response syndrome(SIRS)in early diagnosis of multiple organ dysfunction syndrome(MODS).Methods: Plasma tumor necrosis factor-α(TNF-α)?interleukin-1β(IL-1β)and interleukin-6(IL-6)levels in 30 patients with SIRS by enzyme-linked immunosorbent assay(ELISA).Results: Plasma TNF-α?IL-1β and IL-6 levels were elevated obviously and kept in high level in 30 cases,and there were significantly differences between patients with SIRS and controls(all P<0.01).Also,levels in MODS group were markedly higher than that in non-MODS group(P<0.01 and P<0.05).Conclusion:The inflammatory cytokines may participate in the onset and development of MODS.TNF-α?IL-1β and IL-6 are useful in early diagnosis.更多还原