【摘要】 目的 :探讨高脂饮食引起动脉粥样硬化的机理。方法 :采用高脂饮食喂养小鼠,用酶联免疫吸附法检测小鼠血清中OX -LDL含量 ;用RT -PCR法检测小鼠腹腔M -CSFmRNA的表达。结果 :高脂刺激动物体内OX -LDL含量增加和M -CSFmRNA的表达的增强。结论 :高脂刺激动物体内OX -LDL、M -CSF含量的升高 ,加速动脉粥样硬化的形成更多还原

【Abstract】 Objective:To research the mechanism of atherosolerosis(AS) induced by the high-lipid food. Methods: The mouses were fed with the high-lipid food, then the enzyme linked immunosorbent assay (ELISA) was used to determine the content of OX-LDL in serum and reverse transcription-polymerase chain reaction(RT-PCR) was used to determine the expression of M-CSF mRNA in the macrophage in mouse’s ventro-cavity.Results: The high-lipid food could cause both the increase of the content of OX-LDL and enhancement of expression of M-CSF within the body.Conclusion: The high-lipid food may accelerate the development of AS by stimulating the elevation of the content of OX-LD and M-CSF in the body.更多还原