【摘要】 目的　探讨肿瘤坏死因子α(TNFα)在妊娠高血压综合征及胎儿宫内发育迟缓发病中的作用及益气化瘀法提高胎盘血供的内在机制。　方法　采用 L-精氨酸甲酯 (L- NAME)于妊娠第 10 d起皮下注射制作模型 ,黄芪、丹参复方成分及硝酸甘油干预 ,于妊娠 12 d起测尾动脉血压 ,考马斯亮兰法检测尿蛋白含量 ,妊娠第 18d用 EL ISA法检测血浆TNFα水平下降 (P<0 .0 1) ,而阳性组 TNFα水平不仅未降低 ,反而有所升高 ,但差异无统计学意义。　结论　以益气化瘀立法的黄芪丹参复方成分舒张血管、降低外周阻力 ,改善胎盘循环的作用可能是通过抑制 TNFα分泌而实现的更多还原

【Abstract】 Objective To explore the role of TNFα played in Pregnancy Induced Hypertension(PIH) and intrauterine growth retardation (IUGR) and the mechanism of the improvement of placenta blood supply by composition of Huangqi-Danshen. Methods On day 10, Hyped rats L-NAME after they were pregnant, and the composistion of Huangqi-Danshen, Glonoin was added by celiac-injection at the meantime. On day 12 of pregnancy, blood pressure of caudal artery and urinary protein level were measured. On day 18 of pregnancy, plasma TNFα content were tested by ELISA. Result The TNFα level of the model group was higher than the physical pregenacy group(P<0 05). Treat group was lower than the model group(P<0.01). There was insignificant difference between the masculine group and the model group. Conclusion The composition of Huangqi-danshen can dilatate the vas cular, reduce resistance of blood and improve placenta circulation更多还原