【摘要】 目的　建立人体器官组织中超微量稀土元素的测定方法。　方法　样品经 HNO3+ H2 O2 微波消解体系消解后 ,以铑作为内标 ,直接用电感耦合等离子体质谱法 ( ICP- MS)测定人体肝脏中超微量稀土元素镧、铈、镨、钕、钐、铕、钆、铽、镝、钬、铒、铥、镱、镥。　结果　方法快速、灵敏、准确 ,14个稀土元素的检出限分别在 0 .8～ 4μg/ L :线性良好 ,可达 3个数量级以上 ,线性相关系数均≥ 0 .997;精密度良好 RSD<3 % ;回收率在 98%～ 113 %之间 ,对人发标准物质 GBW0 760 1及小麦粉标准物质 GBW0 85 0 3测定 ,结果满意。　结论　 ICP- MS法是测定人体肝脏组织中超微量稀土元素有效的分析方法 ,内标元素 Rh可补偿基体效应 ,质谱干扰可用干扰校正系数校正更多还原

【Abstract】 Objective To establish the method for determination of rare earth elements at ultratrace levels in human organ. Methods The samples were digested by closed-vessel microwave HNO 3+H 2O 2 dissolution system. The solution was directly analyzed by ICP-MS for determination of La?Ce?Pr?Nd?Sm?Eu?Gd?Tb?Dy?Ho?Er?Tm?Yb?Lu in human liver with rhodium internal calibration. Result The method provided excellent sensitivity and accuracy. It was efficient for determination of fourteen REEs. The detection limits ranged from 0.8 μg/L to 4 μg/L depending on the elements. Linear calibration plots exhibited over three orders of magnitude with standard linear correlation r≥0.997. Recoveries of spiked samples were of the range 98%～113% and precisions were of <30% RSD. The results obtanied showed close agreement with the reference values in two standard reference materials of Human Hair GBW07601 and Wheat Flour GBW08503. Conclusion The method was accurate and reliable. Using Rh as an internal standard may compensate the depression of signal. The problem of the molecular overlaps was corrected by the interference correction factor.更多还原