【摘要】 目的　研究年龄范围在 2 1～ 5 0岁健康成年人外周血淋巴细胞HPRT基因位点突变率及其影响因素。方法　用多核细胞法检测淋巴细胞HPRT基因位点突变率 ,拟合HPRT基因位点突变率与年龄的相关函数。结果　成年人淋巴细胞HPRT基因位点突变率与年龄的相关函数为 :y =0 .75 5 5 +0 .0 44 0x ,r =0 .982 9(P <0 .0 5 )。吸烟对健康成人HPRT基因突变率有影响 (P <0 .0 5 ) ,而不同性别间无显著差异 (P >0 .0 5 )。结论　成年人HPRT基因位点突变率随年龄增长而增加 ,年递增率为 0 .0 44 0‰ ;吸烟对HPRT基因突变有影响 ,而性别则无影响。更多还原

【Abstract】 Objective To study the HPRT gene loci mutation frequencies and the factor of influence in peripheral blood lymphocytes of adult with ages ranging from 21～50.Methods HPRT gene mutation frequency (GMf) were examined by the technique of multinuclear cell assay.Relation between GMf and years were fitted with a computer.Results Relation could be described by the following equantion:y=0.7555+0.0440x,r=0.9829.Smoking has influence on GMf and sex hasn’t.Conclusion HPRT gene mutation frequency increases with increase of age.Increasing rate is 0.0440‰ per year.更多还原