【摘要】 目的 探讨新生儿脐血维生素K缺乏诱导蛋白(PIVKA-Ⅱ)水平是否与胎龄及地区有关。方法采集405例足月儿(平均胎龄39.31周,城镇259例,乡村146例)及142例早产儿(平均胎龄35.90周,城镇116例,乡村26例)脐血,用酶联免疫吸附法测定其PIVKA-Ⅱ水平,≥2μg/ml为阳性。结果 不同胎龄新生儿脐血PIVKA-Ⅱ阳性率无显著差异(P>0.05);城镇足月儿脐血PIVKA-Ⅱ阳性率32.82％,显著低于乡村65.75％(P<0.01),而城镇与乡村早产儿脐血PIVKA-Ⅱ阳性率(42.24％,46.15％)无显著差异(P>0.05)。结论新生儿脐血PIVKA-Ⅱ水平与胎龄无关,与地区有关。更多还原

【Abstract】 Objective To study weather neonatal umbilical serum protein induced by vitamin K absence(PIVKA-Ⅱ) level is associated with gestational age or region. Methods The umbilical cord blood was collected from 405 full term newborns (average gesta-tional age 39.31 weeks, 259 cases of urban, 146 rural cases) and 142 cases of preterm newborns (average gestational age 35.9 weeks, 116 urban cases and 26 rural cases); the cord serum PIVKA-Ⅱ level was determined by means of enzyme-link immunoassay. The level ≥2μg/ml mean positive result. Results There was no significant difference between term neonatal cord serum PIVKA-Ⅱ positive proportion and preterm newborns with varying gestational ages ; urban term neonatal cord serum PIVKA-Ⅱ positive proportion was lower than that of rural term newborns; there was no significant difference between urban and rural preterm neonatal cord serum PIVKA- Ⅱ proportions. Conclusion Neonatal cord serum PIVKA-Ⅱ level is not associated with gestational ages but with regions.更多还原