【摘要】 目的　探讨高脂性脂肪肝与肝纤维化之间的关系。方法　以高脂饮食饲喂 Wistar大鼠 3个月和6个月诱发高脂性脂肪肝模型 ,观察肝脏组织病理学变化 ,测定肝内甘油三酯 (TG)、羟脯氨酸 (H yp)的含量和血浆层粘蛋白 (L N)、透明质酸 (HA)的含量。结果　与对照组相比 ,模型 1组和 2组大鼠肝细胞内有大量的脂滴 ,但间质中无纤维组织。肝内 TG显著增高 ,而 Hyp、L N、H A的含量无明显增加。结论　高脂性脂肪肝与肝纤维化之间并无直接关系 ;脂肪肝是否合并肝纤维化可能与病因、病情缓急、病程长短等多种因素有关更多还原

【Abstract】 Objective To explore the correlation between fatty liver and hepatic fibrosis.Methods Thirty Wistar rats were randomized into three groups:normal control group (group Ⅰ),sacrificed for three months with high fat diet group (group Ⅱ),sacrificed for six months with high fat diet group (group Ⅲ).Hepatic histopathological change was observed.Hepatic triglyceride (TG),hydroproline (Hyp) and plasma laminin (LN),hyaluronic acid (HA) contents were measured.Results As compared with group Ⅰ,steatosis was observed,but no fibre tissue observed in the liver in group Ⅱ,Ⅲ animals.Hepatic TG content was increased significantly,but Hyp,LN and HA content was not increased significantly in group Ⅱ,Ⅲ animals.Conclusion There is no direct relationship between fatty liver and hepatic fibrosis on the chronical high fat diet.The problem whether fatty liver is complicated by fibrosis may involve many factors such as cause,course,and state of the disease.更多还原