【摘要】 目的　探讨nm2 3-H1基因在大肠癌组织中的表达及与预后的相关性。方法　应用免疫组织化学SP法检测了 12 0例大肠癌组织中nm2 3-H1的表达。结果　nm2 3-H1在本组大肠癌组织中阳性表达率为 6 0 83%(73/12 0 )。nm2 3-H1蛋白的表达与肿瘤的组织学分级有关 ,高、中分化腺癌中nm2 3-H1蛋白阳性表达率明显高于低分化腺癌 (P <0 0 5 )。nm2 3-H1蛋白的表达与大肠癌预后有关 ,nm2 3-H1蛋白阳性表达组术后生存率明显高于阴性表达组 (P <0 0 0 1)。结论　nm2 3-H1基因可能是影响大肠癌患者生存的一个重要预后指标。更多还原

【Abstract】 Objective To investigate the expression of nm23-H1 protein and relationship with prognosis in colorectal carcinoma(CRC).Method Streptavidin-Peroxidase immunohistochemical technique was applied to detect the expression of nm23-H1 in 120 cases of CRC.Results The results showed that positive expression rate of nm23-H1 was 60.83%(73/120). nm23-H1 gene expression was related to the histological grade (P<0.05). The cases of nm23-H1 gene positive expression had much higher survival rate than those of negative expression (P<0.001). Conclusion nm23-H1 may be an important prognostic factor in the survival of patients with CRC.更多还原