【摘要】 目的 :观察尿激酶静脉溶栓治疗急性肺栓塞的疗效及安全性。方法 :将 30例急性肺栓塞患者随机分为 A、B两组。 A组 :于 2 h内静脉滴入生理盐水 10 0 m L +尿激酶 2万 U/ kg,同时应用低分子肝素钙 5 0 0 0 U、皮下注射每 12h1次 ,连用 7d,于停用低分子肝素钙前 3d开始服用华法令 ,华法令总疗程 6个月。 B组 :仅应用低分子肝素钙及华法令 ,应用方法同 A组。观察临床症状、体征及螺旋 CT检查的变化。结果 :尿激酶静脉溶栓治疗急性肺栓塞的总有效率为 75 % ,明显高于单纯抗凝治疗组的 2 0 % ,两者比较差异显著 (P<0 .0 1)。溶栓治疗组出血的发生率为 15 % ,且仅为皮肤粘膜的轻微出血 ,一般不需处理自行停止。与单纯抗凝组相比无显著差异 (P>0 .0 5 )。结论 :尿激酶静脉溶栓治疗急性肺栓塞疗效显著而又安全可靠 ,值得推广应用更多还原

【Abstract】 Objective:The purpose of this study was to evaluat the efficacy and safety of intavenous thrombolytic therapy using urokinase(UK) in acute pulmonary embolism(APE).Methods:Thirty patients With APE were randomly divided into two groups (A and B),twenty patients in group A were given N.S 100mL+UK 20000 IU/kg ivdrip in two hours,in addition to anticoagulant thereapy,and Ten patients in group B were given anticoagulant therapy alone.The results were compared,Results:The total effective rate of group A(thrombolytic group)was 75 %,and it was significantly higher than that of group B(anticoagulant group 20 %).The minor bleeding rate of the thrombolytic group was 15 %,without severe side-effect.Conclusions:UK intravenous thrombolytic therapy is a effective,reliable and safe method for APE.更多还原