【摘要】 目的 :探讨氯沙坦对球囊成形术后兔血管内膜增殖的影响。方法 :将 2 4只新西兰兔随机分为三组 :对照组、模型组及氯沙坦组。后两组持续给予 1.5 %高胆固醇喂养 ,实验初始行腹主动脉内膜剥脱术 ,8周后对狭窄部位行球囊成形术 ,氯沙坦组于球囊成形术前 1周开始口服氯沙坦 10 m g/ (kg· d)。 12周末取腹主动脉行病理形态学观察。结果 :氯沙坦组内膜厚度 (IT)减少 6 5 % ,内膜面积 (IA )减少 34% ,内膜厚度比中膜厚度 (IT/ MT)减少 32 % ,内膜面积比中膜面积 (IA/ MA)减少 2 8% (P<0 .0 1)。结论 :氯沙坦在不影响血脂的情况下明显抑制血管损伤后内膜增殖更多还原

【Abstract】 Objective:To investigate the effects of losartan on the neointimal proliferation after balloon angioplasty in rabbits.Methods:Twenty four rabbits were divided randomly into three groups at random:control group,model group and losartan group.The latter two groups were fed with 1.5 % cholesterol diet for 12 weeks.At first the celiac arterial endothelium were denuded.Then they were underwent balloon angioplasty in the celiac artery after 8 weeks.From 1 week before balloon angioplasty losartan group were supplemented by losartan 10 mg/(kg·d).Then the arteries were harvested for morphological observation.Results:Treatment with losartan significantly reduced neointimal thickness(IT) reduce to 65 %,neointimal area(IA) reduce to 34 %,IT/MT reduce to 32 %,IA/MA reduce to 28 %( P <0.01).Conclusion:The therapy of losartan could reduce the neointimal proliferation induced by balloon injury in rabbits without effects on the serrum triglyceride and total cholesterol.更多还原