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质谱和核磁共振成为研究生物大分子的重要方法——简介2002年诺贝尔化学奖得主的贡献
MASS SPECTROMETRY AND NUCLEAR MAGNETIC RESONANCE BECOME THE IMPORTENT METHODS TO STUDY BIOLOGICAL MACROMOLECULES--BRIEF INTRODUCTION OF THE CONTRIBUTIONS OF NOBLE PRIZE LAUREATES IN CHEMISTRY 2002
【摘要】 2002年诺贝尔化学奖授予了在质谱和核磁共振领域有杰出贡献的三位科学家。John B. Fenn和Koichi Tanaka发展了质谱鉴定生物大分子质量的方法,Kurt Wüthrich建立了核磁共振测定蛋白质分子溶液三维结构的方法。他们的研究成果是质谱和核磁共振方法发展的里程碑,极大地推动了这两种研究方法的进一步发展。如今,质谱和核磁共振已发展成为认识生物大分子的强劲的研究手段。
【Abstract】 The Noble prize in chemistry for 2002 is being shared between three scientists who have made brilliant contributions in two important fields: mass spectrometry(MS) and nuclear magnetic reso-nance (NMR). The laureates, John B. Fenn and Koichi Tanaka have developed the methods for identify-ing the mass of biological macromolecules by MS. Kurt W ü thrich has established a method for determin-ing the 3D solution structures of proteins by NMR. Their remarkably scientific achievements are the milestones in the developments of MS and NMR, and have promoted greatly the further development of these two methods. Nowadays, MS and NMR have become the two of most powerful research techniques used to embrace the biological macromolecules.
【Key words】 Noble prize; Mass spectrometry; Electrospray ionization; Soft laser desorption ionization; Nuclear magnetic resonance; Biological macromolecules;
- 【文献出处】 生物物理学报 ,Acta Biophysica Sinica , 编辑部邮箱 ,2002年04期
- 【分类号】Q71
- 【被引频次】10
- 【下载频次】951