【摘要】 为了解纯钛阳极氧化伴水热处理的技术路线及羟基磷灰石薄涂层在体内的成骨效应 ,以钛片为阳极 ,β-磷酸甘油钠和醋酸钙为电解质 ,经 2 0 0～ 40 0 V直流电解 15 min,维持电流密度≤ 5 0 m A/ cm2 ,而后经 2 80℃～30 0℃水热处理 2 h,取光滑、喷砂表面作对照 ,分别植入 12只兔股骨内 ,在术后 4、8、16周取出带种植体骨块制作磨片 ,观察新骨生成情况及术后 8周光滑和涂层种植体的界面超微结构 ,并作表面能谱分析。结果发现水热处理后 ,钛片表面出现了羟基磷灰石涂层 ,动物实验显示涂层种植体 8周后编织骨的转化和成熟较快 ,未见剥脱的羟基磷灰石碎片 ,其表面的钙、磷含量在种植后增加明显。这说明阳极氧化伴水热处理可以制备出纯钛表面羟基磷灰石薄涂层 ,其早期促编织骨形成作用明显 ,可以加快编织骨转化成板层骨更多还原

【Abstract】 To study the method of anodic oxidation followed by hydrothermal treatment for cp titanium and to know bone response to thin hydroxyapatite layers in vivo, commercially pure titanium plates were anodized at 200V～400V with direct electric current density no more than 50 mA/cm 2 for 15 minutes in the electrolytic trough. β-glycerophosphate sodium(0.03~0.04M) and calcium acetate(0.2~0.3M) were used as electrolytes. Then, titanium plates were hydrothermal treated in the autoclave for 2 hours at 280℃～300℃. Polishing and grit-blasting surface was used as control to learn bone response to thin layers. Twelve rabbits were evenly divided into 3 groups, each group was implanted with 12 implants into the rabbits femoral bone. After 4? 8 and 16 weeks, implants were taken out and collected respectively and were made grinding slices. The bone-implant interface was observed with light microscope. And the bone-implant interface of polishing and layered implants after 8 weeks implantation was observed with scanning electron microscope. The element contents at the interface of polishing and layered implants before and after 8 weeks implantation were detected with EDAX. Results showed that there was hydroxyapatite(HA) precipitated on the titanium surfaceamellae bone in 8 weeks for thin HA coatings, and no HA debris were found at the interfacial zone. In addition, Ca and P content on the hydrothermal treated implant surface increased much more after implantation than that of polished implants. It was concluded that anodic oxidation followed by hydrothermal treatment could precipitate thin hydroxyapatie layer on the surface of cp titanium, which could improve early formation of woven bone and accelerate woven bone transferring to lamellae bone at the implanted site.更多还原